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Add-On Therapy: Spironolactone Tablet, Film Coated.
(*) Company : Pfizer.
Patent : Expired
TradeMark: ALDACTONE
UpDate: 2019. 04.08.




Cardio.>DiUretics. SpironoLactone Oral Suspension. 25 mg/5 mL.
Antagonist of Aldosterone.
- Indications:
treatment of NYHA Class III-IV heart
failure and reduced ejection fraction
to increase survival, manage edema,
and to reduce the need for
hospitalization for heart failure; use
as an add-on therapy for the treatment
of hypertension, to lower blood
pressure; the management of edema in
adult cirrhotic patients when edema is
not responsive to fluid and sodium
restrictions.
USA Approval Date: 2017. 08.07.
USA Launch Date : 2017. 10.30.
(*) Company; Patent; TradeMark & Web-
Site Available on Request.
UpDate: 2019. 04.01




Cardio.>Pulmonary Arterial Hypertension. Treat.: Epoprostenol for Inj.
USA Approval Date: 2005. 06.
USA Launch Date : 2010. 04.
(*) Company; Patents; TradeMark & Web-
Site Available on Request.
UpDate: 2019. 04.01.




Cardio.>Pulmonary Arterial Hypertension. Treat.: Macitentan Tablets.
DE Launch Date : 2014. 01.
JP Launch Date : 2015. 06.
USA Launch Date : 2013. 11.
(*) Company; Patents; TradeMark & Web-
Site Available on Request.
UpDate: 2019. 04.19.




Cardio.>Pulmonary Arterial Hypertension. Treat.: Selexipag Tablets.
DE Launch Date : 2016. 06.
USA Launch Date: 2016. 01.
(*) Company; Patents; TradeMark & Web-
Site Available on Request.
UpDate: 2019. 04.19.




Cardio.>Pulmonary Arterial Hypertension. Treat.: Treprostinil. Implant System.
Synthetic Analog of Prostacyclin.
USA Approval Date: 2018. 07.31.
(*) Companies; Patents; TradeMarks &
Web-Site Available on Request.
UpDate: 2020. 03.02.




Cardio.>Pulmonary Arterial Hypertension. Treat.: Treprostinil Inhalation Solu-tion. Synthetic Analog of Prostacyclin.
USA Approval Date: 2009. 07.30.
(*) Company; Patents; TradeMark & Web-
Site Available on Request.
UpDate: 2020. 07.26.




Cardio.>Pulmonary Arterial Hypertension. Treat.: Treprostinil. Injection. SubCu- taneous.
Synthetic Analog of Prostacyclin.
USA Approval (Drug) Date: ?
USA Approval (Pump) Date: 2020. 02.24.>
>PreFillable by Specialty Pharmacies.
(*) Companies; Patents; TradeMarks &
Web-Sites Available on Request.
UpDate: 2020. 03.02.




Cardio.>Pulmonary Arterial Hypertension. Treat.: Treprostinil. Oral. ER Tablets.
Synthetic Analog of Prostacyclin.
USA Approval Date: 2013. 12.20.
(*) Company; Patents; TradeMark & Web-
Site Available on Request.
UpDate: 2020. 03.02.




Cardio.>TREAT.: Eplerenone Tablets
Brand.
Mechanism: Aldosterone AntAgonist.
JP Approval Date : 2007. 07.31.
USA Approval Date: 2002. 09.27.
(*) Company; Patents; TradeMarks & Web-
Site Available on Request.
UpDate: 2019. 02.18.




Cardio.>HyperTension. TREAT.: Enalapril Maleate Oral Solution.
USA Approval Date: 2013. 08.14.
(*) Company; Patents; TradeMark & Web-
Site Available on Request.
UpDate: 2019. 07.14.




Cardio.>HyperTension. TREAT.: Implanta- ble Technology.
EU Approval Date: 2011. 08.25.
(*) Company; Patents; TradeMark & Web-
Site Available on Request.
UpDate: 2019. 07.16.




Cardio.>HyperTension. TREAT.: Lisinopril Oral Solution.
USA Approval Date: 2016. 07.29.
(*) Company; Patents: TradeMark & Web-
Site Available on Request.
UpDate: 2019. 07.14.





Cardio.>HyperTension. TREAT.: NeuroModu-
lation Device.
EU CE Mark Date: 2019. 09.04.
(*) Company; Patents; TradeMark & Web-
Site Available on Request.
UpDate: 2019. 12.11.




Cardio.>HyperTension. TREAT.: UltraSound (US) Renal DeNervation System.
EU CE Mark Date: 2012. 02.19.
(*) Company; Patents; TradeMark & Web-
Site Available on Request.
UpDate: 2021. 02.08.




Cardio.>HyperTension+OsteoArthritis. Treat.: Amlodipine Besylate+Celecoxib Tablets.
USA Approval Date: 2018. 05.31.
(*) Companies; Patents; TradeMark &
Web-Site Available on Request.
UpDate: 2020. 03.15.




Critical Care Medicine>Short Term Treat.: Nicardipine.HCl Premixed Inj.
(*) Company; Patents; TradeMark & Web-
Site Available on Request.
UpDate: 2019. 02.19.




Medication Adherence. UrinAnalysis.
Launch Date: 2018. 02.01.
(*) Company : Aegis Sciences Corp.
www.aegislabs.com.
TradeMark: KardiAssure.
Web-Site : www.aegislabs.com/our-
services/kardiassure/
UpDate: 2018. 02.02.




Pulmonary Arterial Hypertension. Treat.:
Tadalafil Tablets USP, 20 mg. Generics.
USA Launch Date: 2018. 08.13.
(*) Company: Mylan NV.
UpDate: 2018. 08.14.




TREAT.: Acebutolol.HCl Capsules. Generic
(*) Company: Mylan
UpDate: 2019. 02.18.




TREAT.: Amlodipine Besylate Tablets.
(Brand)
Initial USA Approval: 1992.
(*) Company : Pfizer.
Patent : Expired
TradeMark: NORVASC
UpDate: 2019. 03.20.




TREAT.: Amlodipine Besylate Tablets.
(Generic)
(*) Company: Teva Pharma.
UpDate: 2019. 03.21.




TREAT.: Amlodipine Oral Suspension.
USA Approval Date: 2019. 07.10.
USA Launch Date: 2019. 09.25.
(*) Company : Azurity Pharma.
TradeMark: Katerzia
UpDate: 2019. 09.26.




TREAT.: Atenolol Oral Solution.
USA Launch Date: 2019. 03.25.
(*) Company: CutisPharma Inc.
UpDate: 2019. 03.26.




TREAT.: Atenolol Tablets. Generic.
(*) Company: Mylan
UpDate: 2019. 02.18.




TREAT.: CandeSartan Cilexetil+HydroChlo- ro Thiazide Tablets.
Approved in JP & USA
(*) Company : Takeda Pharma.
Patent : Expired
TradeMark: Blopress® Plus
UpDate: 2019. 03.27.




TREAT.: Carvedilol Tablets.
Initial U.S. Approval: 1995.
(*) Company : GSK
Patent : Expired
TradeMark: Coreg
UpDate: 2019. 03.27.




TREAT.: Carvedilol Phosphate ER Capsules
Brand
Initial U.S. Approval: 1995.
(*) Company : GSK
Patent : Expired
TradeMark: Coreg CR
UpDate: 2019. 03.28.




TREAT.: Carvedilol Phosphate ER Capsules
Generic.
USA Tentative Approval Date: 2017. 12.08
(*) Company: Impax Laboratories Inc
UpDate: 2019. 03.28.




TREAT.: Eplerenone Tablets. Generic.
(*) Company: Greenstone LLC.
UpDate: 2019. 02.18.




TREAT.: Irbesartan Tablets. Brand.
(*) Company : Sanofi.
Patent : Expired
TradeMark: Avapro
Web-Site :
products.sanofi.ca/en/avapro.pdf
UpDate: 2019. 02.25.




TREAT.: Nicardipine.HCl Capsules. Gene-
ric.
(*) Company: Mylan.
UpDate: 2019. 02.18.




TREAT.: Nifedipine ER Tablets. Brand.
(*) Company (Ex USA) : Bayer
Company (USA) : Pfizer
Patent : Expired
TradeMark (Ex USA): Adalat
TradeMark (USA) : ProCardia XL
Web-Site (Ex USA) :
www.adalat.com/en/professional/
Web-Site (USA) :
www.pfizer.com/products/product-
detail/procardia
UpDate: 2019. 02.20.




TREAT.: Nifedipine ER Tablets. Generic.
(*) Company: Mylan
UpDate: 2019. 02.20.




TREAT.: Perindopril Erbumine. Generic.
CA Launch Date: 2018. 03.07.
(*) Company: Sandoz Canada.
UpDate: 2018. 03.08.




TREAT.: Perindopril Erbumine/Indapamide.
Generic.
CA Launch Date: 2018. 03.07.
(*) Company: Sandoz Canada.
UpDate: 2018. 03.08.




TREAT.: Sodium Nitroprusside Injection 25mg/mL, 2mL Single Dose Vial. Generic.
Indicated for the Immediate Reduction of Blood Pressure of Adult and Pediatric Patients in Hypertensive Crisis.
USA Approval Date: 2017. 12.19.
(*) Company : Amphastar Pharmaceuticals
Inc.
Web-Site: www.amphastar.com
UpDate: 2017. 12.20.




TREAT.: Valsartan Oral Solution.
Angiotensin II Receptor Blocker.
USA Approval Date: 2017. 12.19.
(*) Company : Carmel Biosciences
www.carmelbio.com
Licensee : Medicure Intl.
www.medicure.com
License Agreement Signed
on 2017. 10.31.
Carmel Biosciences ACQ. By Nutri-
band Inc. (nutriband.com) on
2018. 09.26.
TradeMark: Prexxartan.
UpDate: 2019. 03.24.







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