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Section:	Main.PEDIATRICS.Pneumology.Respiratory Distress Syndrome.Treatment.Surfactants..PorActant Alfa.NonGeneric PorActant Alfa.Patent..Claims.Claim 1: Animal Lung Surfactant:.a) Polar PhosphoLipids (98.5-99%);.PhosphatidylCholine (>70-75%).DiPalmitoylPhosphatidylCholine.(40-45%) & b) Hydrophobic Low MW.(3-14 KD) Proteins (<1.5%). Claim.2: Prepn. Process: a) Triturate.Animal Lungs; b) Wash Triturated.Lungs in Salt Soln & Filter Off.Filtrates=Solid Fraction (SF). c).Centrifuging SF. d) Extract with.Organic Solvent. e) Evaporate Solve.nt & f) Recover Polar Comp. by.Gel Chromatography. Claim 3: (f).Chromatography in Inverse Phase on.LIPIDEX -5000.RTM. Column, with.1,2-DiChloroEthane/MeOH 1:4 (V/V)..Claim 4: Pharma. Compn for Cure of.Infant Respiratory Distress Syndrom.e in Premature Infants Suspension.Vials Inhalation or EndoTracheal.Adm. Contg Surfactant Concn.:.50-100 mg/ml. Patent Assignee
Code:	59779
Product:	Italy. C
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