| CORP. SALE | Fosmidomycin = OCH-N(OH)-(CH2)3-PO3H2 . Na |
| MECHANISM OF ACTION |
The pathway is 1-DEOXY-D-XYLULOSE 5-PHOSPHATE, which is responsible for the synthesis of the building blocks of isoprenoids - compds such as sterols & steroid hormones. The researchers discovered that by shutting down this pathway, malaria parasites are not able to survive. They chose 2 drugs, FOSMIDOMYCIN & one of its derivs to shut down the DOXP pathway. The drugs inhibit DOXP reducto-isomerase, as demonstrated in experiments with the isolated recombinant enzyme. In addition, the drugs killed PLASMODIUM FALCIPA RUM - the parasite responsible for the most lethal form of malaria - in cell culture & cured mice infected with P. VINCK EI, the rodent malaria parasite. The deriv. compd was twice as effective as fosmidomycin. The low toxicity of the drugs allowed doses as high as 300 mg/kg of body wt to be administered; however, the short half-lives of the drugs meant that doses were required every 8 hours |
| UPDATE | 09.99 |
| AUTHOR |
Beck Ewald, prof Jomaa Hassan |
| LITERATURE REF. | Science, 285, p. 1573 (1999) |
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