| LITERATURE REF. |
Design & synthesis: M.A. Ondetti et al., Science 196, p. 441 (1977); D.W. Cushman et al., Biochemistry 16, p. 5484 (1977). Improved synthesis: D.H. Nam et al., Eur. J. Pharmacol. 51, p. 377 (1978). Clinical studies: D.B. Case et al., ibid. 195; H.R. Brunner et al., Ann. Int. Med. 90, p. 19 (1979). Toxicology & Metabolism: G.R. Keim in Captopril & Hypertension, D.B. Case, Ed. (Plenum, New York, 1980) p. 137. GC/MS determn. in biol. fluids: T. Ito, Y. Matsuki, J. Chromatog. 417, p. 79 (1987). Historical review & comprehensive bibliography: Z.P. Horovitz in Pharmacological & Biochemical Properties of Drug Substances vol. 3, M.E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1981) pp 148 - 175. Comprehensive description: H. Kadin in Analytical Profiles of Drug Substances vol. 11, K. Florey, Ed. (Academic Press, New York 1982), p. 79 - 137. Reviews: Am. Heart J. 104, pt. 2, 1125 - 1228 (1982); Brit. J. Clin. Pharmacol. 14, Suppl. 2, 69S-252S (1982). Series of articles on pharmacology & therapeutic efficacy: Postgrad. Med. J. 62, Suppl. 1, 1 - 191 (1986)
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