Main > LIPID > Bases > Sphingolipid Base Prepn

Product Phytosphingosine. Ceramide. Analog. NE. G.

CORP. SALE Me-(CH2)x-(CHOH)2-CH(CH2OH)-NHCO-(CH2)9-OH; x =
10 - 25
PATENT ASSIGNEE'S COUNTRY Netherlands
UPDATE 07.99
PATENT ASSIGNEE This data is not available for free
PATENT CLAIMS Prepn method
- Prepg omega-hydroxyacid of formula: HO-(CH2)9-COOH
- Reacting morpholine & cyclic ketone to form enamine, 1-
morpholino-cycloalkene
- Coupling enamine with omega-acyloxy alkanoyl chloride
- Hydrolyzing morpholino group from prodt to form 2-(omega-
acyloxy alkanoyl)-cycloketone (I)
- Hydrolyzing carbonyl in (I) to form linear intermediate (II)
- Reducing to methylene the carbonyl of (II)
PATENT PHOTOCOPY Available on request

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