| COMMENTS |
who specializes in enantioselective synthesis, says the findings "constitute a fundamentally important advance in asymmetric catalysis and combinatorial chemistry." In the new technique, a contact printer is used to deposit spots of chiral product onto a glass slide. A coupling reagent is included in the spotting solution so that the enantiomeric products become covalently attached to surface groups on the slide. Two fluorescent chiral probe reagents—a green one for one enantiomeric product and a red one for the other—are added to each spot simultaneously. The two probe reagents react with the enantiomers at different rates, a process known as kinetic resolution. Fluorescence from each spot on the slide is measured with a laser scanner to determine the degree of incorporation of chiral product. These data are then entered into an equation developed by the late French chemist Alain Horeau of the Collège de France in Paris that calculates enantiomeric excess from kinetic resolution data. The red-green ratio also can indicate the absolute configuration of a product if a study on the reactivity of the enantiomers with the red and green probes has been carried out in advance. |
| UPDATE | 01.01 |
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