| PATENT NUMBER | This data is not available for free |
| PATENT ASSIGNEE | This data is not available for free |
| PATENT EXAMPLES |
The ability of selected 2-methylpropanamide derivatives to block maximal electroshock-induced seizures (MES) was determined by the following procedure. Seizures were induced by application of current (50 mA, 60 pulses/sec, 0.8 msec pulse width, 1 sec duration, D.C.) using a Ugo Basile ECT device (model 7801). Mice were restrained by gripping the loose skin on their dorsal surface and saline-coated corneal electrodes were held lightly against the two cornea. Current was applied and mice were observed for a period of up to 30 sec for the occurrence of a tonic hindlimb extensor response. A tonic seizure was defined as a hindlimb extension in excess of 90 degrees from plane of the body. The 2-methylpropanamides tested were administered iv to mice 10 min before the test procedure. TABLE 1 Activity of Substituted Benzylamino 2-methylpropanamide in MES iv in mouse Example iv MES activity (number Substituent No. protected/number screened) 4-fluorophenoxy 2 8/8 3,4-methylenedioxyphenoxy 2 8/8 2,4-difluorophenoxy 2 8/8 5-indanoxy 2 1/8 |
|
Want more information ? Interested in the hidden information ? Click here and do your request. |