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| PATENT EXAMPLES |
(2) Amino Diacid Monomers: The monomer is based on three naturally occurring amino diacids: L-aspartic acid, L-glutamic acid and L-.alpha.-aminoadipic acid. For the small amounts of amino acids being degraded in controlled release implants, it is unlikely that any toxicity would occur. ##STR6## The amino group on the amino acid must be blocked to prevent polypeptide formation during polymerization. However, the choice of blocking agent provides a convenient way to control polymer hydrophobicity and crystallinity. The blocking groups to be used are naturally occurring saturated fatty acids of differing lengths (to control hydrophobicity) or benzoic acid. ##STR7## As discussed above, the hydrophobicity and crystallinity will regulate erosion rate. These properties may also vary depending on which of the three amino acids are employed. ##STR8## The monomers shown above are a combination of two naturally occurring molecules and it is unlikely that they are toxic as they can be eliminated directly by the body. Alternatively, the peptide linkage can be hydrolytically or enzymatically (by a non-specific protease) cleaved to yield the amino acid and benzoic or saturated fatty acid |
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