| TECHNOLOGY |
Co. 1's (Australia) technology is solid-phase synthesis. The Co. has developed specific protection & deprotection tactics for each of the 5 OH or NH2 group positions on a pyranose. In particular, the Co. has developed a deriv. of dimedone that can bind to & protect an NH2 group &/or link a sugar molecule to a resin. The dimedone is cleavable with hydrazine Rejection of pig tissue transplanted into humans is largely caused by a - Disaccharide of galactose, called diGal [Gal(alpha1 - 3) Gal], on organ cell surfaces The joint project aims to make large amounts of diGal, immobilize diGal on the surface of a column packing, & pass the blood of transplant patients through the column to tie up Ab to diGal |
| UPDATE | 01.01 |
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