| TECHNOLOGY |
At Co., for example, Grignard chemistry is always an option in preparing biaryls. In the Grignard coupling, the organometallic reagent is an arylmagnesium halide. The chemistry complements Suzuki coupling, and whenever it is possible to use the Grignard reaction, the economics often are better, says Co.'s global business director for pharmaceuticals. That's because the Grignard route does not use boronic acids and often produces higher yields than does the Suzuki reaction, Co. says. Moreover, because of Co.'s highly active proprietary palladium catalysts for this coupling, much less palladium is required. Co.'s experience is that up to 70% of the aryl-aryl couplings they get inquiries about can be done through the Grignard route, he says. |
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