| COMMENTS | "The technical obstacles that needed to be surmounted to achieve these results should not be underestimated," comments associate professor of chemistry and biochemistry John T. Koh of the University of Delaware, Newark. "We all knew that selection was the way to go, but the technical difficulties scared most of us away. Through careful analysis of the system and a true tour de force effort, Doyle and coworkers have shown us how to do it right. Using this technology, they could potentially create a family of selective receptors that could be used to independently regulate multiple genes in vivo. There are many exciting possible applications for such systems in biology, medicine, and bioengineering |
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