| RESEARCH |
Nature Materials 3, 829–836 (2004) Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis TORU MORO1, YOSHIO TAKATORI1, KAZUHIKO ISHIHARA2, TOMOHIRO KONNO2, YORINOBU TAKIGAWA3, TOMIHARU MATSUSHITA4, UNG-IL CHUNG1, KOZO NAKAMURA1 and HIROSHI KAWAGUCHI1 1 Department of Sensory & Motor System Medicine, Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo, Tokyo 113-0033, Japan 2 Department of Materials Engineering, School of Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo, Tokyo 113-0033, Japan 3 Materials Research and Development Laboratory, Japan Fine Ceramics Center, Atsuta, Nagoya 456-8587, Japan 4 Japan Medical Materials Corporation, Yodogawa, Osaka 532-0003 Japan Correspondence to: HIROSHI KAWAGUCHI kawaguchi-ort@h.u-tokyo.ac.jp Nature Materials AOP Published online: 24 October 2004 | doi:10.1038/nmat1233 Abstract Periprosthetic osteolysis—bone loss in the vicinity of a prosthesis—is the most serious problem limiting the longevity of artificial joints. It is caused by bone-resorptive responses to wear particles originating from the articulating surface. This study investigated the effects of graft polymerization of our original biocompatible phospholipid polymer 2-methacryloyloxyethyl phosphorylcholine (MPC) onto the polyethylene surface. Mechanical studies using a hip-joint simulator revealed that the MPC grafting markedly decreased the friction and the amount of wear. Osteoclastic bone resorption induced by subperiosteal injection of particles onto mouse calvariae was abolished by the MPC grafting on particles. MPC-grafted particles were shown to be biologically inert by culture systems with respect to phagocytosis and resorptive cytokine secretion by macrophages, subsequent expression of receptor activator of NF-B ligand in osteoblasts, and osteoclastogenesis from bone marrow cells. From the mechanical and biological advantages, we believe that our approach will make a major improvement in artificial joints by preventing periprosthetic osteolysis. This article: View PDF Send to a friend Full Text Figures & Tables Methods References nature jobs Engineering and Physical Sciences Research Council Biotechnology Office of Science and Technology London, United Kingdom Senior Research Scientist Genetics Institute of Bioengineering and Nanotechnology Singapore, Singapore More science jobs |
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