Main > PHARMA. > Drug BioAvailability > Oral Drug BioAvailability > Improvement. > Citrus derived Compds. (USA.B) > Patent > Literature (Claims Etc.) > Claim 1: Process Comprising: 1) > Providing Oil of First-Pass Citrus, > 2) Removing Volatile Materials > by Evaporation, Distn., or Reduced > Pressure to provide Residue, 3) > Extract Residue: Acetonitrile (A) > & Evaporate (A) to provide > Semi-Purified Residue (B), 4) > Wash (B) with Ethanol/Water Mixt., > 5) Extract Washed (B) with (A) to > provide Acetonitrile Soln. (C), 6) > Wash (C) with Alkaline Solvent & > Evaporate (A) to provide Purified > Residue (D), 7) Subject (D) to > Reverse Phase HPLC to provide > Plural Fractions, > One of which > Primary First-Pass Effect Fraction > Claim 2: 1st First-Pass Effect Frac > tion Subject. to Chiral HPLC to

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tion Subject. to Chiral HPLC to's subsections
provide Plural Fractions, > One of

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