Main > RHEUMATOLOGY>OSTEOARTHRITIS > Treatment > Cox-2 Inhibitors (Pain Control) > Etoricoxib > Co.: USA. M (Brand Tablets/Patents) > Process Chemistry

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Co. s researchers have used in situ NIR & IR to track events during the formation of a vinamidinium salt, a key intermediate in the synthesis of etori
coxib. They decided to move to real-
time monitoring of the corrosive reac
tion mixture since identifying a usable
HPLC assay proved difficult. Although NMR spectrometric assays were also po
ssible, they were inconvenient for ope
rations in pilot-plant or mfg. facili
ties. The researchers found they could
effectively track not only starting-
material disappearance & prodt. forma
tion, but transient intermediates as
well.

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