Main > PEPTIDES > Fluorinated Peptides > Org.: USA. T. (Research/Patents) > Work Description
Author et al also have been broadly exploring the insertion of fluorinated amino acids into proteins to imbue them with Teflon-like properties. Author s work includes the design of fluorinated drug delivery systems; potential cancer drugs; and antibiotics, including soon-to-be-published work on magainin-2 and the related AMP buforin-2.
Author et al presented a poster highlighting progress on fluorinating a different type of protein, the gut hormone glucagon-like peptide-1 (GLP-1). This peptide has potential as a drug to treat diabetes and, like other peptides, suffers rapid degradation by proteases, leaving it with a half-life in blood of only a few minutes.
Author et al replaced one or two amino acid residues in GLP-1 with hexafluoroleucine. Like fluorogainin-1, fluorinated GLP-1 proved to have enhanced enzymatic stability over the native version while preserving its biological activity. It also proved to be an effective binder of the GLP-1 receptor and is just as effective as the exenatide analogs.
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